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narcotics, sedatives, hypnotics, anticholinergics, etc.) A patient determined to be brain dead is legally and clinically dead.9.6 The date and time of declaration and the name of the attending neurologist, neuro critical care fellow or attending neurosurgeon declaring death by brain criteria4.3 Toxicology screening negative for significant confounding substances. Oculovestibular reflex.

It is appropriate to write a brief narrative note summarizing the indications for and results of brain death testing as recorded in this document.7.1 Spontaneous 'spinal' reflexes in the limbs (not to be confused with pathologic flexion or extension responses, which are NOT consistent with brain death )Consider ancillary testing if 6.1 and/or 6.2 are observed.2.1 Death by brain criteria is defined under Massachusetts state law as the total and irreversible cessation of spontaneous brain functions, in which further attempts of resuscitation or continued supportive maintenance would not be successful in restoring such function. The test must be performed bilaterally, as well as anteriorly and posteriorly. Most hospitals have a brain death protocol, which must be followed precisely with complete documentation. These guidelines do not replace the physician's judgment in individual cases, since brain death is a clinical diagnosis.3.2 American Academy of Neurology guidelines stipulate that a single full exam, as detailed below, is required to diagnose brain death . with train-of-four nerve stimulation) if neuromuscular blocking agents have been administered recently or for a prolonged period8.4 Transcranial Doppler ultrasonography: Reverberating flow or small systolic peaks in early systole without diastolic flow are consistent with brain death . Renal or hepatic dysfunction, orpreceding hypothermia may prolong clearance.
The extracranial circulation should fill, allowing for uptake within the meninges and skull vessels.3.1 One full exam, including apnea testing, must be performed by an attending neurologist or neurosurgeon, or a neurocritical care fellow under the supervision of a neurology attending, and documented as such.2.2 The three essential findings in brain death are coma, absence of brainstem reflexes, and apnea.

A required checklist for the proper performance of testing is found at the end of this document.4.2 Absence of severe acid-base, electrolyte, or endocrine abnormality that may confound clinical assessment. with a warming blanket, etc).3.4 A member of the Respiratory Therapy department must be present during apnea testing.7.5 Absence of diabetes insipidus (i.e., normal osmolar control mechanism)8.3 Electroencephalography: Absence of any electrocerebral activity during at least 30 minutes of recording.The cardinal findings in brain death are: (1) coma, (2) absence of brainstem reflexes, and (3) apnea.8.1 Conventional angiography: Contrast injected under pressure into the aortic arch. There must be clinical or neuro-imaging evidence of an acute central nervous system catastrophe that is compatible with the clinical diagnosis of death by brain criteria.These manifestations are occasionally seen and may be misinterpreted as evidence for brain stem function.8.5 Insufficient data exists to support the use of CT angiography, MRI, MR angiography, or somatosensory evoked potentials for brain death determination, thus these are not currently considered acceptable ancillary tests.4.4 Demonstrated absence of neuromuscular blockade by electrical stimulation (e.g.

The study alone should not be used to confirm brain death. The external carotid circulation is patent, and delayed filling of the superior sagittal sinus may be seen.7.2 Respiratory-like movements (shoulder elevation and adduction, back arching, intercostal expansion without significant tidal volumes) that may trigger the ventilator to deliver a breath4.6 Stable systolic blood pressure >= 100 mmHg. 4 Protocol oBackground o Brain death leads to sudden reduction in circulating pituitary hormones o May be responsible for impairment in myocardial cell metabolism and contractility which leads to myocardial dysfunction o Severe dysfunction may lead to extreme hypotension and loss of organs for transplant o ECHO after 6 hours of starting T4 o Heart cath