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*, Tavares-Cadete F.*, Young A. N.*, Sugar R., Schoenfelder S., Ferreira L., Wingett S. , Andrews S., Grey W., Ewels P.A., Herman B., Happe S., Higgs A., LeProust E., Follows G.A., Fraser P., Luscombe N.M., Osborne C.S.Nature Genetics; 2017 Mar;49(3):403-415 Warren H.R. Dr. Mifsud joined the William Harvey Research Insitute in QMUL as an MRC eMedLab Career Development Fellow and Lecturer in 2015, where she used chromatin interaction data to understand the function of regulatory GWAS mutations. *, Martincorena I.
Here we use Capture Hi-C (CHi-C), an adapted genome conformation assay, to examine the long-range interactions of almost 22,000 promoters in 2 human blood cell types. Here we use Capture Hi-C (CHi-C), an adapted genome conformation assay, to examine the long-range interactions of almost 22,000 promoters in 2 human blood cell … Her work with Thomas Jenuwein involved the epigenetic characterisation of a histone methylation deficient mouse model. Dr. Mifsud has been an Assistant Professor at HBKU since July 2018. In her postdoctoral work she focussed on developing methods for the analysis of Hi-C type data and finding new biological insights into transcriptional regulation, by applying these methods to Hi-C and capture Hi-C data sets. Transcriptionally active genes contact enhancer-like elements, whereas transcriptionally inactive genes interact with previously uncharacterized elements marked by repressive features that may act as long-range silencers. Ramírez J., Duijvenboden S.V. “Mapping Long-Range Promoter Contacts in Human Cells with High-Resolution Capture Hi-C.” Nature Genetics, May. *, Gao H.*, Ren M*., Mifsud B. Finally, we show that interacting loci are enriched for disease-associated SNPs, suggesting how distal mutations may disrupt the regulation of relevant genes. Ntalla I., Mifsud B., Warren H.R., Tzanis E., Orini M., Tinker A., Lambiase P.D., Munroe P.B.Nature Genetics; 2015 Oct;47(10):1179-86 Schoenfelder S.*, Sugar R.*, Dimond A. We identify over 1.6 million shared and cell type-restricted interactions spanning hundreds of kilobases between promoters and distal loci. This study provides new insights and accessible tools to dissect the regulatory interactions that underlie normal and aberrant gene regulation. After her molecular biology training, she started bioinformatics in the laboratory of Professor Nicholas Luscombe at EMBL European Bioinformatics Institute (EBI) in Cambridge, and subsequently moved to UCL and the Crick Institute in London. View JSON March 28th, 2019 at 6:42pm. Transcriptional control in large genomes often requires looping interactions between distal DNA elements, such as enhancers and target promoters.
We developed Promoter Capture Hi-C (PCHi-C) to enable the genome-wide detection of distal promoter-interacting regions (PIRs), for all promoters in a single experiment.
Overview.
*, Evangelou E.*, Cabrera C.P.
2015; Mifsud et al. *, Mosen-Ansorena D.*, Mifsud B. *, Darbo E., Sugar R., Schoenfelder S., Fraser P., Luscombe N.M.National Centre for Epidemiology, Budapest, HungaryEBML European Bioinformatics Institute; Cambridge, UKNature Communications; 2018 May 16;9(1):1947. Current chromosome conformation capture techniques do not offer sufficiently high resolution to interrogate these regulatory interactions on a genomic scale.
ExperimentType Capture Hi-C. released. Mifsud graduated in biology from Eotvos Lorand University in Budapest in 2006 and obtained her PhD from the Institute of Molecular Pathology in Vienna in 2010. *, Tavares-Cadete F.*, Sugar R., Javierre B-M., Nagano T., Katsman Y., Sakthidevi M., Wingett S. W., Dimitrova E., Dimond A., Edelman L. B., Elderkin S., Tabbada K., Darbo E., Andrews S., Herman B., Higgs A., LeProust E., Osborne C.S., Mitchell J.A., Luscombe N.M., Fraser P.William Harvey Research Institute; Queen Mary University London, UKUniversity College London and the Francis Crick Instiute, London, UKInstitute of Molecular Pathology, Vienna, AustriaDepartment of Plant Taxonomy, Eotvos Lorand University, Budapest, HungaryEotvos Lorand University, HungaryDr. *, Javierre B-M.*, Armstrong H.*, Mifsud B., Dimitrova E., Tavares-Cadete F., Furlan-Magaril M., Jurkowski W., Segonds-Pichon A., Wingett S., Tabbada K., Andrews S., Herman B., LeProust E., Osborne C.S., Koseki H., Fraser P., Luscombe N.M., Elderkin S.Nature Genetics; 2015 Jun;47(6):598-606 Mifsud B. …
Nature 506 (7488): 376–81. 2015). Nature Genetics; 2018 Sep; doi: 10.1038/s41588-018-0205-x Evangelou E.*, Warren H.R. In her postdoctoral work she focussed on developing methods for the analysis of Hi-C type data and finding new biological insights into transcriptional regulation, by applying these methods to Hi-C and capture Hi-C data sets. We demonstrate its functionality by integrating a recent promoter capture Hi-C dataset (Mifsud et al., 2015) with publically available GWAS summary statistics (http://www.immunobase.org), Ensembl gene annotations (Cunningham et al., 2015) and Roadmap epigenomics chromatin segmentation states (Roadmap Epigenomics et al., 2015). Here we use Capture Hi-C (CHi-C), an adapted genome conformation assay, to examine the long-range interactions of almost 22,000 promoters in 2 human blood cell types. 2015.